Thiol-derivatized minihepcidins retain biological activity

Investigation of thiol derivatized gold nanoparticle sensors for gas analysis

Thiol-Derivatized Nanocrystalline Arrays of Gold, Silver, and Platinum

A simple procedure has been developed to prepare thiol-derivatized nanoparticles of metals. The procedure involves the transfer of well-characterized metal hydrosols to a hydrocarbon medium containing the thiol. Thiol-derivatized nanoparticles Au, Ag, and Pt of near spherical shape forming nanocrystalline arrays have been characterized by X-ray diffraction, transmission electron microscopy (TEM...

Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity

Relaxin-3 or insulin-like peptide 7 (INSL7) is the most recently discovered relaxin/insulin-like family peptide. Mature relaxin-3 consists of an A chain and a B chain held by disulphide bonds. According to structure activity relationship studies, the relaxin-3 B chain is more important in binding and activating the receptor. RXFP3 (also known as Relaxin-3 receptor 1, GPCR 135, somatostatin- and...

Electrochemical studies of derivatized thiol self-assembled monolayers on gold electrode in the presence of surfactants.

Electrochemical impendence spectroscopy (EIS), cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were performed to investigate the barrier properties and electron transfer of derivatized thiol self-assembled monolayers (SAMs) on gold in the presence of surfactants. The thiol derivatives used included 2-mercaptoethanesulfonic acid (MES), 2-mercaptoacetic acid (MAA), and N-acetyl-L...

Biological disulfides: the third messenger? Modulation of phosphofructokinase activity by thiol/disulfide exchange.

Rabbit muscle phosphofructokinase is rapidly inactivated at pH 8.0 by incubation with low concentrations of oxidized glutathione, Coenzyme A glutathione mixed disulfide, and oxidized Coenzyme A. The inactivation is first order in disulfide concentration over the concentration ranges examined (50-200 microM), and is approximately 8-fold slower at pH 7.0 than at pH 8.0. The substrates ATP and fru...